Evaluation the Anti-Diabetic Activity of Cherry Laurel (Laurocerasus officinalis)

Purpose: Cherry laurel has been used as an anti-diabetic drug. In this study, we aimed to evaluate its antidiabetic activity at standard living conditions and under stress by an experimental study. Material and Method: Forty Wistar-Albino rats weighing 300–350 grams were used in this study. Four groups were structured: control, diabetic, glibenclamide and cherry laurel extract. Streptozotocin (50 mg/kg) was injected to induce diabetes. Cherry laurel extract was obtained from the seed of the fruit. Routine blood glucose, insulin, preand intraanesthesia blood glucose levels were measured and compared. The One-way ANOVA followed by Duncan post-hoc test was used for statistical analysis. Results: After the second week of the experiment, Extract 300 and Extract 600 groups had the lower glucose levels (p<0.05). Also, insulin levels measured at the last week of the study revealed that Extract 300 and Extract 600 groups had the highest results (p< 0.01). Glucose levels under stress conditions significantly changed for Extract 300 and glibenclamide group (p<0.05). Glucose level changed more obviously in the Extract 600 group (p<0.001) that means